Huperzine A

Huperzine A is a reversible AChE inhibitor that prevents the degradation of endogenous acetylcholine and was used to releave the memory loss and other cognitive defects of Alzheimer's patients .

Where are Huperzine A come from ?

Huperzine A is the active constituent with memory-enhancing properties found in the club moss, Huperzia serrata (Thunb.). For centuries, this plant has been brewed as an herbal tea in China for the treatment many diseases such as blood loss, fever, as a diuretic and for irregular menstruation. The club moss is found on the ground deep in damp forests and in rock crevices.

How Huperzine A react with AChE ?

Huperzine A appears to be a very well crafted invention of Mother Nature that is capable of filling the active site of the enyzme acetylcholinesterase, the enzyme that degrades the neurotransmitter acetylcholine. Because of its high potency as an acetylcholinesterase inhibitor, huperzine A has found use as an safe and effective agent in improving memory and learning, especially in individuals suffering form early stage or moderate forms of Alzheimer's disease. Clinical studies are now planned that will more carefully examine whether huperzine A is capable of slowing the progession of this insidious disease. While undoubtedly more research now underway may establish other mechanisms of action for this molecule, such as those involved in its ability to block glutamate toxicity, Huperzine A is currently available as an over the counter "nutriceutical.

Images to click and see:

The simple presentation of the structure Huperzine A

The 3D view of AChE with Huperzine A

The 3D presentation with the side branches of the AChE with Huperzine A